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[DOI] [PubMed] [Google Scholar] 150.Bhatt DL, Szarek M, Steg PG, et al

Special considerations : For patients taking tirzepatide (Mounjaro, Zepbound), note that it may reduce the effectiveness of oral contraceptives during initiation and dose escalation

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These include anyone with a history of alcohol use disorder (alcohol withdrawal or dependence increases risk during medication use), patients taking concurrent diabetes medications that lower blood sugar, and those with liver disease or reduced liver function